Research, News and Events

James was invited to present and be part of an expert panel at the Complications in Medical Aesthetics Collaborative Annual Meeting. The subject for discussion was vision loss secondary to dermal filler. James is leading the UK steering group to produce guidelines for management of this condition. He was joined on the expert panel by contributors from Australia, Vietnam and Norway.

Stereotactic radiotherapy for neovascular age-related macular degeneration (STAR): a pivotal, non-commercial, randomised, double-masked, sham-controlled device trial

This research on age-related macular degeneration and radiotherapy was presented in Barcelona at EURetina 2024.

Is there a role for internal limiting membrane peeling and gas tamponade in the treatment of vitreomacular traction by vitrectomy?

This research on vitrectomy and vitreomacular traction was presented in Barcelona at EURetina 2024.

Mr. Neffendorf was invited by the RNIB charity to review and update their factsheet on age-related macular deneration (AMD) and anti-vascular endothelial growth factor (anti-VEGF) treatment. These are medications that are used to treat wet AMD. The webpage also contains a video featuring Mr. Neffendorf and one of his AMD patients that was produced 10 years ago.

Read more

Stereotactic radiotherapy for neovascular age-related macular degeneration (STAR): a pivotal, randomised, double-masked, sham-controlled device trial

Mr Neffendorf was part of a research team which published this pivotal research in The Lancet. The work reports the findings from a major trial assessing the use of stereotactic radiotherapy in age-related macular degeneration.

Read more

Mr. Neffendorf was invited to attend and present at this new retinal surgical meeting in Oslo, Norway. It brought together Vitreoretinal Surgeons from throughout Europe to share research, innovation and surgical technique.

Mr Neffendorf was invited to judge the presentations of London Ophthalmic Surgical Trainees at the Théa presentation evening. The quality of presentation submissions was high, with a focus on safety and learning from surgical mistakes. The winning presentation was on the subject of vision loss due to inflammation inside the eye.

When is a 'one-stop' cataract service not a 'one-stop' service?

Mr Neffendorf led on this research looking at the efficiency of appointments for patients being assessed for cataract.

Read more

The implantable miniature telescope (IMT) new developments: The US and UK experience

Abstract published from the 2023 European Association for Vision and Eye Research Festival. Mr Neffendorf has been involved in telescopic IOL research since 2015.

Read More

Mr Neffendorf was invited to contribute on the expert panel about chromovitrectomy. This relates to the use of dyes during vitreoretinal surgery to aid surgery on the macula, for example during macular hole or epiretinal membrane procedures.

Mr Neffendorf was asked to give a presentation on the retina and it's blood supply. He sat on the expert panel at the CMAC Annual Meeting with colleagues from around the globe.

Myopia in late adolescence and subsequent multiple sclerosis among men

Mr. Neffendorf collaborated with neurologists and epidemiologists on this study of over 1 million Swedish men to investigate risk factors for multiple sclerosis.

Read more

Effect of intravitreal anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration on renal function

Mr Neffendorf led on this research investigating whether injections used for AMD might affect kidney function.

Read more

Retinal toxicity secondary to subconjunctival cefuroxime following pars plana vitrectomy: A case report and literature review

Mr Neffendorf supervised a medical student to publish this case report.

Read more

Epimacular brachytherapy for previously treated neovascular age-related macular degeneration: month 36 results of the MERLOT randomised controlled trial

Mr Neffendorf was part of the research team investigating the use of epimacular brachytherapy for age-related macular degeneration.

Read more

The effect of intravitreal ocriplasmin on hue discrimination

Mr. Neffendorf led on this study investigating whether ocriplasmin treatment affects colour vision.

Read more

Confidence of UK ophthalmology registrars in managing posterior capsular rupture: results from a national trainee survey

Mr. Neffendorf was part of a research team that surveyed UK ophthalmology trainees to assess their ability to handle complications of cataract surgery.

Read More

Diagnostic sensitivity of vitrectomy and vitreous biopsy for vitritis

Mr Neffendorf was part of a research team looking at the diagnostic potential of vitrectomy in patients with uveitis (inflammation of the eye).

Read more

Re: Concept and application of relaxing radial retinectomy for retinal detachment with advanced proliferative vitreoretinopathy

A response published to an article on the management of complex retinal detachment

Read more

Litigation in ophthalmology against the National Health Service in England

This research looked at cases of litigation against the NHS and was published in a leading international journal.

Read more

Safety of intracameral cefuroxime in pars plana vitrectomy

Mr. Neffendorf led on this large database research study of over 7,000 patients looking at safety of retinal surgery.

Read more

Urgency of retinal detachment repair: is it time to re-think our priorities?

Published research in Eye (Nature) looking at urgency of retinal detachment surgery.

Read more

Effect of aqueous dynamics on gas behavior following retinal reattachmnet surgery

Mr Neffendorf led on this mathematical theoretical study assessing gas behaviour in retinal surgery.

Read more

Evaluation of month-24 efficacy and safety of epimacular brachytherapy for previously treated neovascular age-related macular degeneration. The MERLOT randomised clinical trial

Mr Neffendorf was part of the research team at King's for this large study of AMD patients that was published in the prestigious JAMA Ophthalmology journal.

Read more

Personal protective equipment (PPE) for vitreoretinal surgery during COVID-19

Mr Neffendorf was invited to join a group asked to publish advice and standards for PPE during vitreoretinal surgery during the COVID pandemic.

Read more

Intravitreal ranibizumab for persistent diabetic vitreous haemorrhage: a randomised, double-masked, placebo-controlled feasibility study

Mr Neffendorf was part of the team at King's that published this research on patients with vitreous haemorrhage due to diabetes.

Read more

Improved diagnosis of retinal laser injuries using near-infrared autofluorescence

Mr Neffendorf was part of the team who published this research on retinal laser injuries

Read more

Handheld laser devices and laser-induced retinopathy (LIR) in children: an overview of the literature

Mr Neffendorf led on this major review of laser pointer injuries which was published in Eye (Nature).

Read more

Considerations for using Natalizumab treatment in patients with a history of choroidal melanoma

Mr Neffendorf led the team that published this work on patients with choroidal melanoma.

Read more

Intraoperative and postoperative complications in phacovitrectomy for epiretinal membrane and macular hole: a clinical audit of 1,000 consecutive eyes

Mr Neffendorf was a member of the research team at St. Thomas' Hospital, London, which published this research into patients undergoing combined cataract and retinal surgery for macular hole or epiretinal membrane.

Read more

The role of intraocular gas tamponade in rhegmatogenous retinal detachment. A synthesis of the literature

Mr Neffendorf was first author on this review paper of gas used in retinal detachment surgery.

Read more

Ocriplasmin for symptomatic vitreomacular adhesion

This Cochrane Review was published at King's with Mr Neffendorf as first author. Cochrane reviews are complex projects with stringent research methodology that are used to provide the highest level of evidence.

Read more

Intravitreal gas for symptomatic vitreomacular adhesion: a synthesis of the literature

Mr Neffendorf was the first author on this research paper of patients with vitreomacular traction and macular hole.

Read more

StereoTactic radiotherapy for wet Age-Related macular degeneration (STAR): study protocol for a randomised controlled clinical trial

This research protocol for the STAR AMD study was published by the team at King's in Trials Journal.

Read more

Ethnic Variation in Vitreoretinal Surgery: Differences in Clinical Presentation and Outcome

Mr Neffendorf was part of the retinal research team at St. Thomas' Hospital which published this research on retinal detachment.

Read more

Intraoperative Complications of Patients Undergoing Small-Gauge and 20-Gauge Vitrectomy: A Database Study of 4,274 Procedures

This research on patients undergoing retinal surgery was published in European Journal of Ophthalmology.

Read more

Widespread macular neurosensory detachment after ocriplasmin intravitreal injection

This case report was published on the subject of treatment of vitreomacular traction.

Read more

Hydrodynamic Radii of Ranibizumab, Aflibercept and Bevacizumab Measured by Time-Resolved Phosphorescence Anisotropy

Mr Neffendorf was part of the research team at King's College London investigating pharmacology of anti-VEGF drugs which are used in retinal diseases such as AMD, diabetic macular oedema and retinal vein occlusion.

Read more

Trends and emerging patterns of practice in vitreoretinal surgery

This publication looked at various aspects of vitreoretinal surgery.

Read more

Epimacular brachytherapy for previously treated neovascular age-related macular degeneration (MERLOT): A phase 3 randomized controlled trial

Mr Neffendorf was part of the research team at King's which published this major trial into the use of radiation in the treatment of AMD.

Read more

Stereotactic radiotherapy for wet age-related macular degeneration: current perspectives

A review article on age-related macular degeneration.

Read more

Subretinal Visual Implant Alpha IMS – Clinical trial interim report

Mr Neffendorf was a contributor to this research project on the use of a visual implant to restore vision in patients with retinal degeneration.

Read more

Efficacy and safety of phenylephrine 2.5% with cyclopentolate 0.5% for retinopathy of prematurity screening in 1246 eye examinations

This research was published on safety of dilating drops used to examine the retina in retinopathy of prematurity screening.

Read more

Kestenbaum's capillary number terst - a forgotten sign?

Revisiting the value of a test to look at the health of the optic nerve.

Read more

Adult alveolar rhabdomyosarcoma of the lacrimal sac

A case report on a rare condition was published in Orbit Journal.

Read more

Ibrutinib in relapsed chronic lymphocytic leukemia

A publication in the prestigious New England Journal of Medicine.

Read more